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Local Anesthetic >> Tetracaine >> Tetracaine Hydrochloride

Product Name: Tetracaine hydrochloride
Chemical Name: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
Other Name: 2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride
CAS Number:136-47-0
EINECS Number:205-248-5
M.F.: C15H24N2O2.HCl
M.W.:300.83


Quality Standard:BP2009;EP7;USP35

Tetracaine (INN, also known as amethocaine; trade name Pontocaine and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically inophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

ITEMS

SPECIFICATION

Appearance

White crystalline powder

Identification

A.R.C in pass

PH

4.5 to 6.5

Chromatographic purity

Conforms

Heavy Metals

MAX. 10 ppm

Clarity

Clear

Residue on ignition

MAX. 0.1%

Melting range

145 to 150

Loss on drying

MAX. 0.5%

Related substances

Not more than the reference solution

(0.05)%

Assay by HPLC

C15H24N2O2.HCl 98% to 101%

Total Aerobes Count

Yeast & Mold

E.Coli.

Salmonella

Max.1000cfu/g

Max.100cfu/g

Negative

Negative

 

Click:3192  Input time:2013-5-31 【Type】 【Return
 
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